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Goltsov Sergey
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Watch what you take, otherwise... you'll get better!

Stories from the clap bar continue…

Few of my colleagues remember the glorious time when not only a comprehensive approach based on objective knowledge was used in the treatment of skin diseases and sexually transmitted infections, but also Immunostimulants were used, especially for the treatment of late forms of syphilis. 

But in this place it would be necessary to remember that the origins of immunotropic therapy, in fact, go back to the distant past, when the well-known adventures of count Cagliostro treated patients with syphilis (and himself as well), with... crystal balls. Crushed into small crumbs, they poured into a Cup of coffee, which, gulped down, immediately caused massive intestinal bleeding, accompanied, as is known, an increase in body temperature to 40 degrees. So if the patient didn't die of bleeding and convulsions, he was... cured of syphilis. 

Another example was the way doctors in nineteenth – century Russia, in an abundance of wetlands, treated syphilis by walking patients through swamps inhabited by mosquitoes carrying malaria Plasmodium-the causative agent of malaria. Malaria also caused body temperature to rise to 40 degrees for several days, and if the patient did not die from malaria, then... he was recovering from syphilis.

However, in the story I want to tell, it was like this.

Twenty years ago, for the treatment of late forms of syphilis, of course, in complex therapy, the drug Pirogenal was used, which moderately stimulated nonspecific immunity, while increasing body temperature. It was produced in ampoules, and doses were calculated in IVD (minimum pyrogenic doses), the maximum dose was 1000 IVD per day.

But everything is changing in our fleeting world, and at some point Pirogenal began to be dosed, like other injectable drugs, in micrograms per ml of solution. The maximum dose was considered to be 100 µg per day. But did not take into account these innovations nurse treatment room and, accustomed to the figure with three zeros, she prepared a dose to the patient in 10 times the allowable. 

Acrobatic sketches of 160-kilogram patient due to the terrible convulsive syndrome, hyperthermia 40+, respiratory arrest and other equally vivid symptoms could not expect even the doctors of the intensive care team who have seen a lot. The nurse's prolonged hysteria to the heart-rending screams of her neighbors, terrified by the information about the "new complex therapy" of their disease, completed the fullness of the drama observed by all.

How, after all, it's good to be fat. Say, while the thick dries, thin dies. So it is in our story: the excess weight saved the patient's life, and hyperthermia from a repeatedly exceeded dose of pyrogenal saved him from syphilis, and the need to continue treatment with antibiotics, crystal balls and mosquito bites that carry malaria.

Because Treponema pallid, the causative agent of syphilis, dies at 39.7 degrees.

Ещё в блоге:

Phenotypic dermatology
Phenotypic dermatology

Quite early on, I realized that to truly help a large number of patients, I needed to go beyond the individual approach and create a methodology. I recall the words of Edith Piaf, who said, "I don't sing for everyone—I sing for everyone." And yet, she sang for everyone. So it was for me—there was that inspiration, that moment when the idea of ​​phenotypic dermatology first arose. It was from this moment that the path to a systemic view of the skin began—not as a surface, but as an entire biological universe.

One of the cities obligatory for visiting on the way to the Papuans – Jakarta
One of the cities obligatory for visiting on the way to the Papuans – Jakarta

I want to take a breath – we have done it! The expedition Live Parallel 2013 – Papua New Guinea where we walked many kilometers through the jungle, spent tens of kilometers inside the tarantas and hundreds of kilometers on board small planes flying on the same principle as a route-taxi, has come to an end without loss and above all with the result! But it could be otherwise… Well, let us not talk about sad things but about interesting ones, so… Jakarta was the first place to see.

 

Нескромно представлюсь, Вильям Генри Гейтс III
Нескромно представлюсь, Вильям Генри Гейтс III

Стаффордширский бультерьер является самой популярной породой в Лондоне. 

I recognize you from a thousand

Piogenic cocci, in the case of weakening the properties of the immune system of the skin (Yes, it is in the case of weakening the properties of immunity, because the normally functioning skin easily copes with numerous attacks of pyogenic microorganisms), can provoke the development of an island-inflammatory disease – pyoderma. Read more...