The ability to recover is the most important property of the skin, which determines the tendency to close the defect "at any cost". It is noteworthy that the closure can be with or without a scar. Traditionally, healing is characterized by two variants of tension. Primary tension occurs without suppuration and the formation of interstitial tissue with the subsequent development of a linear scar, proceeds in wounds with smooth and viable margins, lagging behind by not more than 1 cm, in the absence of wound infection. By secondary tension, the wound is closed through suppuration with the formation of a visible connective tissue and the subsequent development of a coarse rumen, occurs with the development of wound infection and the presence of defects that do not allow to close the walls of the wound. The processes of inflammation and hypoxia contribute to the excessive activation of fibroblasts, which actively produce collagen, the excess of which can disrupt the natural healing process and create a substandard scar.
As mentioned earlier, the wound process can be considered as a set of various reactions of the organism, developing successively in the wound in response to tissue damage and foreign agents. The Celgel agent used for the local treatment of wounds was developed taking into account the phase of the course of the wound process and corresponds to the basic medical and biological requirements for similar drugs.
The active substance of the Celgel agent, derived from the extract of chicken embryo cells, is characterized by ease of application to the skin upon entering any wound, interacts with niche cells and with stem cells of the basal layer, hair follicle or vascular endothelium, acting as a catalyst for granulation activity, stimulating Own germinal pool in the wound. This gives grounds to speak of directed and justified stimulation of the non-scarified path of healing. And, in contrast to ointments, does not lead to a violation of the outflow of wound detachable and chronic inflammation.
When using Zhegel, a uniform formation of connective tissue throughout the defect is noted. Epithelization is successful - the epidermis has all the signs of differentiation, is not dystrophically changed. Subcutaneous fatty tissue in the inflammatory processes is not involved. Clinically, it is always noted that the reddening and puffiness of the skin decreases on the first day after application, the dermis is restructured with the growth of the granulation pool, the migration and proliferation of fibroblasts, keratinocytes, endothelial cells and other cells are promoted, contributing to the restoration of skin elasticity, reducing the recovery time, in the absence Risk of complications. It is possible to say with certainty that the wound healing agent Zhelgel "launches" the mechanisms of physiological reparative regeneration.
These phenomena can be observed in a number of examples of the use of Celgel in the healing of wounds of various etiologies.